The metabolism of sulphonamides.
نویسندگان
چکیده
p-Aminomethylbenzenesulphonamide (I) was first described by Miller, Sprague, Kissinger & McBurney (1940), and is used in therapy as its hydrochloride, Ambamide (formerly Marfanil). Its antibacterial properties were studied by Klartr (1941) who found it to be less active than sulphanilamide against streptococci, but more active against anaerobic bacteria (cf. Schoop & Stoltz, 1941 Hamre, Walker, Dunham, van Dyke & Rake, 1944; Lawrence, 1945). It differs chemically from sulphanilamide (II) in that its amino group is aliphatic. Unlike sulphanilamide, its antibacterial action is not inhibited by p-aminobenzoic acid and is immediate, showing no latent
منابع مشابه
The metabolism of four sulphonamides in cows.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 40 2 شماره
صفحات -
تاریخ انتشار 1946